Protease inhibitor I8, cysteine-rich trypsin inhibitor-like <p>This domain is found in proteinase inhibitors as well as in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.</p><p>This inhibitor domain belongs to MEROPS inhibitor family I8 (clan IA). Proteins containing this domain inhibit peptidases belonging to families S1 (<db_xref db="INTERPRO" dbkey="IPR001254"/>), S8 (<db_xref db="INTERPRO" dbkey="IPR000209"/>), and M4 (<db_xref db="INTERPRO" dbkey="IPR001570"/>) [<cite idref="PUB00014133"/>] and are restricted to the chordata, nematoda, arthropoda and echinodermata. Examples of proteins containing this domain are:</p><ul><li>chymotrypsin/elastase inhibitor from <taxon tax_id="6253">Ascaris suum</taxon> (pig roundworm)</li><li>Acp62F protein from <taxon tax_id="7227">Drosophila melanogaster</taxon> </li><li>Bombina trypsin inhibitor from <taxon tax_id="161274">Bombina maxima</taxon> (large-webbed bell toad)</li><li>Bombyx subtilisin inhibitor from <taxon tax_id="7091">Bombyx mori</taxon> (silk moth)</li><li>von Willebrand factor</li></ul>